Suppression of lung cancer with siRNA targeting PTTG
نویسندگان
چکیده
منابع مشابه
Suppression of lung cancer with siRNA targeting PTTG.
Pituitary transforming gene (PTTG) is frequently expressed at high levels in malignant tumors. We report high levels of expression of PTTG in various lung tumors and tumor-derived cell lines. For a better understanding of its role in maintaining the cancer phenotype, we used RNA interference (RNAi) directed against PTTG. Transfection of H1299 cells with PTTG siRNA duplex (5'-UGG GAG AUC UCA AGU...
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متن کاملEffects of silencing PTTG expression by small interference RNA.
OBJECTIVE We investigated the effects of small interference RNA (siRNA) on the cell proliferation inhibition, sensitivity to radiotherapy effects and cell apoptosis. The siRNA used here was specific to the pituitary tumor transforming gene (PTTG). MATERIALS AND METHODS Vectors containing the specific functional siRNAs for PTTG were designed and constructed. Cells were divided into four groups...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2006
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.29.2.387